Hangover supplements
Investigation into the common ingredients across popular hangover supplements to understand what's actually in them and whether there are any concerns about mixing them.
The Products
- Happy Tuesday – A UK-based supplement with four separate capsules (Rebalance, Reboot, Release, Restore)
- Myrkl – A probiotic-based supplement from Sweden
- Upside – A Korean herbal jelly
Full Ingredient Breakdown
| Category |
Compound |
Amount |
Source |
Product |
% RDI |
| B Vitamins |
|
|
|
|
|
|
B2 (Riboflavin Phosphate) |
7mg |
Restore |
Happy Tuesday |
500% |
|
B3 (Nicotinamide) |
50mg |
Rebalance |
Happy Tuesday |
313% |
|
B5 (Calcium Pantothenate) |
150mg |
Reboot |
Happy Tuesday |
2,500% |
|
B6 (Pyridoxal Phosphate) |
10mg |
Rebalance |
Happy Tuesday |
714% |
|
B12 |
? |
Myrkl |
Myrkl |
? |
|
Biotin |
500mcg |
Restore |
Happy Tuesday |
1,000% |
|
Folate (5-MTHF) |
400mcg |
Reboot |
Happy Tuesday |
200% |
| Other Vitamins |
|
|
|
|
|
|
Vitamin C (Sodium Ascorbate) |
500mg |
Restore |
Happy Tuesday |
625% |
|
Vitamin D3 (Cholecalciferol) |
25mcg |
Rebalance |
Happy Tuesday |
500% |
|
Vitamin E (D-Alpha Tocopherol Succinate) |
50mg |
Restore |
Happy Tuesday |
417% |
|
Beta-Carotene |
3.75mg |
Restore |
Happy Tuesday |
~75% |
| Minerals |
|
|
|
|
|
|
Magnesium Bisglycinate |
112mg |
Release |
Happy Tuesday |
30% |
|
Zinc Picolinate |
10mg |
Restore |
Happy Tuesday |
100% |
|
Manganese Bisglycinate |
3mg |
Restore |
Happy Tuesday |
150% |
|
Selenium (L-Selenomethionine) |
10mcg |
Restore |
Happy Tuesday |
18% |
|
Iodine (Potassium Iodide) |
100mcg |
Reboot |
Happy Tuesday |
67% |
| Amino Acids & Derivatives |
|
|
|
|
|
|
L-Tyrosine |
400mg |
Reboot |
Happy Tuesday |
n/a |
|
5-HTP (Griffonia Seed Extract) |
100mg |
Rebalance |
Happy Tuesday |
n/a |
|
N-Acetyl L-Cysteine |
200mg |
Restore |
Happy Tuesday |
n/a |
|
L-Cysteine |
? |
Myrkl |
Myrkl |
n/a |
|
L-Taurine |
100mg |
Restore |
Happy Tuesday |
n/a |
| Antioxidants |
|
|
|
|
|
|
Alpha Lipoic Acid |
200mg |
Restore |
Happy Tuesday |
n/a |
|
Curcumin |
190mg |
Rebalance |
Happy Tuesday |
n/a |
| Adaptogens |
|
|
|
|
|
|
Ashwagandha Root Extract (10:1) |
100mg eq. |
Release |
Happy Tuesday |
n/a |
|
American Ginseng Extract (4:1) |
100mg eq. |
Release |
Happy Tuesday |
n/a |
|
Rhodiola Rosea Extract (15:1) |
50mg eq. |
Release |
Happy Tuesday |
n/a |
| Probiotics |
|
|
|
|
|
|
AB0001 |
? |
Myrkl |
Myrkl |
n/a |
| Herbal Extracts |
|
|
|
|
|
|
Hovenia Dulcis (contains DHM) |
? |
– |
Upside |
n/a |
|
Hardy Orange |
? |
– |
Upside |
n/a |
|
Kudzu |
? |
– |
Upside |
n/a |
|
Poria Mushroom |
? |
– |
Upside |
n/a |
|
Chinese Cinnamon |
? |
– |
Upside |
n/a |
|
Wolfberry (Goji) |
? |
– |
Upside |
n/a |
|
Black Cardamom |
? |
– |
Upside |
n/a |
|
Satsuma Mandarin Peel |
? |
– |
Upside |
n/a |
|
Ginger Root |
? |
– |
Upside |
n/a |
|
Honeysuckle |
? |
– |
Upside |
n/a |
|
Sickle Senna |
? |
– |
Upside |
n/a |
|
Liquorice |
? |
– |
Upside |
n/a |
| Other Extracts |
|
|
|
|
|
|
Artichoke Extract (5:1) |
50mg eq. |
Restore |
Happy Tuesday |
n/a |
|
Black Pepper Extract |
2.5mg |
Rebalance |
Happy Tuesday |
n/a |
Potential Concerns When Mixing
Direct Overlaps
| Compound |
Products |
Combined Amount |
Concern |
| L-Cysteine / N-Acetyl L-Cysteine |
Myrkl + Happy Tuesday |
? + 200mg |
Same amino acid, different forms |
Functionally Similar (Adaptogens/Stimulants)
| Compound |
Product |
Notes |
| American Ginseng |
Happy Tuesday |
Stimulating adaptogen |
| Kudzu |
Upside |
Can have sedative effects |
| Ashwagandha |
Happy Tuesday |
Adaptogen |
| Rhodiola |
Happy Tuesday |
Stimulating adaptogen |
| Poria Mushroom |
Upside |
Calming adaptogen |
Stacking multiple adaptogens can amplify effects unpredictably – some are stimulating, others calming.
Liver Support Compounds
| Compound |
Product |
| Hovenia Dulcis (DHM) |
Upside |
| Artichoke Extract |
Happy Tuesday |
| Alpha Lipoic Acid |
Happy Tuesday |
| N-Acetyl L-Cysteine |
Happy Tuesday |
| Curcumin |
Happy Tuesday |
These all support liver function and detox pathways – probably fine together but worth noting the overlap in mechanism.
Other Considerations
- 5-HTP (Happy Tuesday) – avoid if taking SSRIs or other serotonergic supplements
- Liquorice (Upside) – can raise blood pressure with regular use
- Ginseng + Ashwagandha + Rhodiola – triple-stacking adaptogens may be overstimulating for some
Notes on RDI Values
- Beta-Carotene RDI calculated as vitamin A equivalent (~625mcg RAE vs 800mcg RDI)
- The 313% RDI shown on Happy Tuesday's label for Magnesium appears to be an error; 112mg elemental magnesium is approximately 30% of the 375mg RDI
- The 182% RDI shown for Selenium also seems high for 10mcg; the typical RDI is 55mcg, making 10mcg approximately 18%
- Amino acids, antioxidants, herbal extracts, and probiotics don't have established RDIs
- Upside doesn't publish specific dosages for their herbal blend